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Esketamine's Role in Treatment-Resistant Depression
Esketamine (Spravato) for treatment-resistant depression: how it works, who qualifies, REMS clinic visits, cost ranges, and Spravato vs IV ketamine.
Why Settling for 'Less Bad' Depression Isn't Enough
Clinicians are pushing for aggressive TRD care aimed at full remission. Here's what that means for patients exploring ketamine treatment options.
BXCL501 Enters Phase 2a Trial for Acute Stress & PTSD
A new DoD-backed Phase 2a trial is testing BXCL501 for acute stress reactions. Here's what it means for the evolving PTSD treatment landscape.
BPL-003 Shows Lasting TRD Relief in Phase 2a Results
New phase 2a data on BPL-003 shows sustained symptom reduction in treatment-resistant depression. Here's what it means for ketamine patients.
New Ketamine Nasal Spray Shows Lasting Depression Relief
BPL-003, a novel ketamine nasal spray for treatment-resistant depression, shows sustained symptom reduction in Phase 2a trials. What patients should know.
Rectal Ketamine Administration: Uses in Pediatric and Palliative Care
How rectal ketamine administration works, its bioavailability and onset, dosing in pediatric sedation, and its role in palliative and hospice pain care.
Norketamine: Ketamine's Primary Metabolite Explained
What norketamine is, its half-life, pharmacological activity vs parent ketamine, and why this metabolite is central to how oral and sublingual ketamine work.
Ketamine and the Opioid System: How Ketamine Interacts with Opioid Receptors
An in-depth exploration of ketamine's interactions with the opioid receptor system, the scientific debate over whether opioid activity contributes to its antidepressant effects, and clinical implications.
Ketamine Compounding Regulations in 2026: What Has Changed
An overview of the latest regulatory developments affecting compounded ketamine in 2026, including FDA enforcement updates, state-level changes, and the impact on patient access.
Ketamine for Tinnitus: Current Research and Mechanisms
An overview of the emerging research on ketamine as a potential treatment for tinnitus, including the glutamatergic theory of tinnitus, clinical evidence, and important limitations.
Ketamine for Chronic Fatigue Syndrome (CFS/ME)
Ketamine is not an approved ME/CFS treatment, but its anti-inflammatory and NMDA-blocking effects have researchers interested. See what the evidence shows.
Ketamine and Epigenetics: How Ketamine May Alter Gene Expression
Ketamine and epigenetics: how histone acetylation, DNA methylation, and microRNA changes may help explain why ketamine's antidepressant effects last for days.