Blog
Latest articles, insights, and updates from the blog.
Contact Ketamine Resource
Send corrections, partnership questions, or advertising inquiries.
mTOR Pathway: Ketamine's Role in Protein Synthesis and Synaptic Growth
A definition of the mTOR (mechanistic target of rapamycin) signaling pathway and its critical role in how ketamine promotes rapid synaptogenesis and antidepressant effects.
Racemic Mixture: S-Ketamine and R-Ketamine Enantiomers Explained
A definition of racemic mixture in the context of ketamine therapy — explaining the S and R enantiomers, their different pharmacological profiles, and clinical implications.
Schedule III Controlled Substance: Ketamine's DEA Classification Explained
Why ketamine is a Schedule III controlled substance: DEA criteria, prescribing rules, refill limits, telehealth implications, and how it compares to II and IV.
Ketamine Clinic Safety Standards: What Patients Should Expect
An overview of emerging safety standards for ketamine treatment clinics, including clinical protocols, monitoring requirements, provider qualifications, and what patients should look for when evaluating a ketamine provider.
First-Pass Metabolism: How Liver Processing Affects Oral Ketamine
A definition of first-pass metabolism — the hepatic processing that reduces oral drug bioavailability — and its specific impact on oral ketamine formulations.
Sub-Anesthetic Dose: The Therapeutic Range for Ketamine in Depression
A definition of sub-anesthetic dosing — the low-dose ketamine range used to treat depression — including typical dosages, rationale, and how it differs from anesthetic use.
GABA (Gamma-Aminobutyric Acid): The Brain's Primary Inhibitory Neurotransmitter
A definition of GABA — the brain's main inhibitory neurotransmitter — and its relationship to ketamine's mechanism of action and therapeutic effects.
Serotonin Syndrome: Risks, Symptoms, and Relevance to Ketamine Therapy
Serotonin syndrome explained: symptoms, drug combinations that trigger it, and why patients on SSRIs or MAOIs need to discuss the risk before starting ketamine.
Ketamine vs SSRIs: How They Compare for Treating Depression
Ketamine vs SSRIs for depression: onset (hours vs weeks), TRD response rates, side effects, dropout rates, monthly cost, and when each is typically prescribed.
Treatment-Resistant Depression (TRD): Definition, Criteria, and Significance for Ketamine
Treatment-resistant depression (TRD) defined: clinical criteria, the two-failed-trials threshold, and why TRD is the primary indication for ketamine therapy.
DEA Telehealth Prescribing Rules: What Changed in 2025
DEA telehealth prescribing rules for controlled substances in 2025: Ryan Haight extensions, in-person visit triggers, and what they mean for ketamine access.
Compounding Pharmacy: Custom Ketamine Formulations Explained
How compounding pharmacies prepare ketamine: troches, lozenges, nasal sprays, 503A vs 503B oversight, FDA limits, and what to ask before ordering.