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CGI-S and CGI-I: Clinical Global Impression Scale Defined
CGI-S and CGI-I are the 1-to-7 clinician-rated severity and improvement scores used alongside MADRS in ketamine and esketamine trials. See how they're scored.
Treatment-Resistant Depression: Why Antidepressants Fail
A Hindu report on treatment-resistant depression explains why antidepressants fail for some patients and where ketamine and esketamine fit in.
The NMDA Hypofunction Model: What Ketamine Research Shows
Ketamine research on NMDA receptor hypofunction shaped how scientists study psychosis. See what studies found and where to learn more.
Compounded Ketamine Safety Oversight: What to Know
Compounded ketamine is not FDA-reviewed for safety or potency. Learn who regulates it, the real risks, and what to ask before starting treatment in 2026.
Ketamine Eases Suicidal Thoughts, But Does It Save Lives?
A 2026 review in Psychiatric Times finds ketamine and ECT rapidly ease suicidal thoughts, but proof they prevent attempts or deaths is limited.
K-Hole Definition: What It Means and Why It Happens
A k-hole is intense, high-dose ketamine dissociation. Learn what causes it, how it differs from clinical dosing, and why treatment avoids it.
Spravato REMS Requirements Explained (2026)
Spravato REMS requires certified clinics, direct observation, and 2-hour monitoring per dose. See what the FDA program covers and how it differs from off-label ketamine.
Ketamine Peak Plasma Concentration by Route: Timing
Learn when ketamine reaches peak plasma concentration by route, what changes the timing, and how to compare methods. Explore route guides.
Severe Nerve Pain and Ketamine: What Toronto Star Found
Toronto Star profiled nerve pain patients seeking relief. Here's what current evidence says about ketamine for chronic neuropathic pain in 2026.
Ketamine Brain Scans Reveal Depression Relief in Seniors
A new report finds ketamine tied to shifting brain activity in older adults with depression. Here's what it means and what remains unclear.
What Is the CADSS Dissociative Scale? Definition Explained
The CADSS dissociative scale measures dissociation intensity in ketamine research. Learn what it scores, who uses it, and how to read results.
Ketamine-Induced Cystitis: What Bladder Research Shows
Ketamine-induced cystitis is a documented bladder toxicity risk tied to heavy, frequent ketamine use. See what the research shows and when to seek care.
Bipolar Depression Ketamine Trial: One Patient's Experience
A clinical trial patient says ketamine changed his life for bipolar depression. Here's what the report does and doesn't tell readers, and how to weigh it.