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BXCL501 Enters Phase 2a Trial for Acute Stress & PTSD
A new DoD-backed Phase 2a trial is testing BXCL501 for acute stress reactions. Here's what it means for the evolving PTSD treatment landscape.
BPL-003 Shows Lasting TRD Relief in Phase 2a Results
New phase 2a data on BPL-003 shows sustained symptom reduction in treatment-resistant depression. Here's what it means for ketamine patients.
New Ketamine Nasal Spray Shows Lasting Depression Relief
BPL-003, a novel ketamine nasal spray for treatment-resistant depression, shows sustained symptom reduction in Phase 2a trials. What patients should know.
Ketamine for Tinnitus: Current Research and Mechanisms
An overview of the emerging research on ketamine as a potential treatment for tinnitus, including the glutamatergic theory of tinnitus, clinical evidence, and important limitations.
Ketamine and the Opioid System: How Ketamine Interacts with Opioid Receptors
An in-depth exploration of ketamine's interactions with the opioid receptor system, the scientific debate over whether opioid activity contributes to its antidepressant effects, and clinical implications.
Ketamine Compounding Regulations in 2026: What Has Changed
An overview of the latest regulatory developments affecting compounded ketamine in 2026, including FDA enforcement updates, state-level changes, and the impact on patient access.
Norketamine: Ketamine's Primary Metabolite Explained
What norketamine is, its half-life, pharmacological activity vs parent ketamine, and why this metabolite is central to how oral and sublingual ketamine work.
Enantiomer: Definition and Relevance to Ketamine
A definition of enantiomers — mirror-image molecular forms — and their critical importance in understanding ketamine's two forms: esketamine (S-ketamine) and arketamine (R-ketamine).
Rectal Ketamine Administration: Uses in Pediatric and Palliative Care
An educational overview of rectal ketamine administration, including its pharmacokinetics, clinical applications in pediatric sedation and palliative care, and how it compares to other routes.
Ketamine for Chronic Fatigue Syndrome (CFS/ME)
An overview of emerging research on ketamine for myalgic encephalomyelitis/chronic fatigue syndrome, including neuroinflammatory mechanisms, clinical evidence, and future directions.
Ketamine and Epigenetics: How Ketamine May Alter Gene Expression
An exploration of emerging research on ketamine's epigenetic mechanisms, including histone modification, DNA methylation changes, and how these processes may contribute to lasting antidepressant effects.
Ketamine vs TMS (Transcranial Magnetic Stimulation): A Clinical Comparison
Ketamine vs TMS (transcranial magnetic stimulation) for depression: how each works, response rates, session counts, side effects, cost, and patient fit.