Ketamine Methods and Routes
IV, IM, intranasal, oral, and sublingual ketamine routes with practical context on bioavailability, onset, monitoring, and tradeoffs.
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Begin with route overviews, then use comparison articles for route-specific tradeoffs and safety considerations.
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Featured
3 articles
Ketamine Dosing Explained: Therapeutic Ranges by Route
Learn how ketamine is dosed for depression and pain across IV, sublingual, intranasal, and IM routes, including titration, sub-anesthetic ranges, and safety.
Rectal Ketamine Administration: Uses in Pediatric and Palliative Care
An educational overview of rectal ketamine administration, including its pharmacokinetics, clinical applications in pediatric sedation and palliative care, and how it compares to other routes.
Ketamine Treatment Methods Guide: Every Route of Administration Explained
A comprehensive comparison of all ketamine delivery methods — IV infusion, intranasal spray, oral and sublingual tablets, intramuscular injection, and ketamine-assisted psychotherapy — covering protocols, bioavailability, costs, pros, and cons.
Ketamine Dosing Explained: Therapeutic Ranges by Route
Learn how ketamine is dosed for depression and pain across IV, sublingual, intranasal, and IM routes, including titration, sub-anesthetic ranges, and safety.
Rectal Ketamine Administration: Uses in Pediatric and Palliative Care
An educational overview of rectal ketamine administration, including its pharmacokinetics, clinical applications in pediatric sedation and palliative care, and how it compares to other routes.
Ketamine Treatment Methods Guide: Every Route of Administration Explained
A comprehensive comparison of all ketamine delivery methods — IV infusion, intranasal spray, oral and sublingual tablets, intramuscular injection, and ketamine-assisted psychotherapy — covering protocols, bioavailability, costs, pros, and cons.
Ketamine Pharmacology: Absorption, Distribution, Metabolism
Ketamine pharmacology explained: absorption by route, distribution, hepatic metabolism to norketamine, half-life, enantiomers, and clinical dosing implications.
Compounded Ketamine Formulations: Lozenges, Troches, and Creams
Compounded ketamine lozenges, troches, nasal sprays, and creams: how compounding pharmacies prepare each, dose ranges, bioavailability, and quality checks.
Intramuscular Ketamine Injection: Administration and Clinical Considerations
Intramuscular (IM) ketamine injection explained: typical dose ranges, bioavailability, onset, clinical use cases, and how IM compares to IV and intranasal.
Oral and Sublingual Ketamine
Oral and sublingual ketamine: how lozenges and troches dose, bioavailability ranges, onset, at-home protocols, and where each fits versus IV or intranasal.
Ketamine-Assisted Psychotherapy (KAP): Integrating Therapy with Treatment
A comprehensive guide to ketamine-assisted psychotherapy — how KAP works, what a session looks like, therapeutic frameworks used, and evidence for enhanced outcomes.
IV Ketamine Infusion
IV ketamine infusion therapy explained: standard 0.5 mg/kg protocol, session length, monitoring, side effects during infusion, and the typical 6-session series.
Continuous and Multi-Day Ketamine Infusions: Extended Protocols
Continuous and multi-day ketamine infusions for chronic pain: extended dosing protocols, indications, monitoring, and how they differ from single sessions.