Ketamine Methods and Routes
IV, IM, intranasal, oral, and sublingual ketamine routes with practical context on bioavailability, onset, monitoring, and tradeoffs.
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Begin with route overviews, then use comparison articles for route-specific tradeoffs and safety considerations.
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Featured
3 articles
Ketamine Dosing Explained: Therapeutic Ranges by Route
See ketamine dosing ranges for depression and pain across IV, intramuscular, intranasal, sublingual, and oral routes, plus how titration and safety checks work.
Rectal Ketamine Administration: Uses in Pediatric and Palliative Care
How rectal ketamine administration works, its bioavailability and onset, dosing in pediatric sedation, and its role in palliative and hospice pain care.
Ketamine Treatment Methods Guide: Every Route of Administration Explained
Compare ketamine treatment methods by bioavailability, dosing, cost, and evidence, including IV infusion, Spravato, oral, sublingual, and IM injection.
Ketamine Dosing Explained: Therapeutic Ranges by Route
See ketamine dosing ranges for depression and pain across IV, intramuscular, intranasal, sublingual, and oral routes, plus how titration and safety checks work.
Rectal Ketamine Administration: Uses in Pediatric and Palliative Care
How rectal ketamine administration works, its bioavailability and onset, dosing in pediatric sedation, and its role in palliative and hospice pain care.
Ketamine Treatment Methods Guide: Every Route of Administration Explained
Compare ketamine treatment methods by bioavailability, dosing, cost, and evidence, including IV infusion, Spravato, oral, sublingual, and IM injection.
Ketamine Pharmacology: Absorption, Distribution, Metabolism
How ketamine is absorbed, distributed, metabolized, and eliminated, covering bioavailability by route, norketamine, HNK metabolites, and elimination half-life.
Compounded Ketamine Formulations: Lozenges, Troches, and Creams
Compounded ketamine formulations include troches, nasal sprays, topical creams, and oral solutions. Compare dosing, bioavailability, and quality checks.
Intramuscular Ketamine Injection: Administration and Clinical Considerations
IM ketamine injection has about 93% bioavailability and reaches peak levels in 5 to 15 minutes. See dosing ranges, uses, technique, and how it compares to IV.
Oral and Sublingual Ketamine
Oral and sublingual ketamine: how lozenges and troches dose, bioavailability ranges, onset, at-home protocols, and where each fits versus IV or intranasal.
Ketamine-Assisted Psychotherapy (KAP): Integrating Therapy with Treatment
A comprehensive guide to ketamine-assisted psychotherapy, how KAP works, what a session looks like, therapeutic frameworks used, and evidence for enhanced outcomes.
IV Ketamine Infusion
IV ketamine infusion therapy explained: standard 0.5 mg/kg protocol, session length, monitoring, side effects during infusion, and the typical 6-session series.
Continuous and Multi-Day Ketamine Infusions: Extended Protocols
Continuous and multi-day ketamine infusions for chronic pain: extended dosing protocols, indications, monitoring, and how they differ from single sessions.