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IV Ketamine Infusion
IV ketamine infusion therapy explained: standard 0.5 mg/kg protocol, session length, monitoring, side effects during infusion, and the typical 6-session series.
Glutamate: The Excitatory Neurotransmitter Central to Ketamine's Action
Glutamate, the brain's excitatory neurotransmitter, and why its post-NMDA-blockade surge is central to how ketamine produces rapid antidepressant effects.
History of Ketamine
History of ketamine from 1962 synthesis to surgical anesthetic, Vietnam-era field use, club drug years, the depression discovery, and FDA approval of Spravato.
Continuous and Multi-Day Ketamine Infusions: Extended Protocols
Continuous and multi-day ketamine infusions for chronic pain: extended dosing protocols, indications, monitoring, and how they differ from single sessions.
Is Ketamine Legal for Therapy?
A clear explanation of ketamine's legal status in the United States and internationally, including FDA-approved uses, off-label prescribing, and controlled substance classification.
Ketamine for Chronic Pain
An overview of how ketamine is used to treat chronic pain conditions, including neuropathic pain, CRPS, fibromyalgia, and central sensitization syndromes.
Neuroplasticity
What neuroplasticity means, how the brain rewires itself, and why neuroplasticity is central to understanding ketamine's rapid antidepressant effects.
Ketamine for Treatment-Resistant Depression
How ketamine therapy is used to treat treatment-resistant depression (TRD), including clinical evidence, response rates, and what patients can expect.
Dissociation
What dissociation means in the context of ketamine therapy — its clinical definition, how it manifests during treatment, and its potential relationship to therapeutic outcomes.
NMDA Receptor
A comprehensive definition and explanation of the NMDA receptor — its role in the brain, its relevance to ketamine therapy, and why it matters for mental health treatment.