Blog
Latest articles, insights, and updates from the blog.
Contact Ketamine Resource
Send corrections, partnership questions, or advertising inquiries.
Intranasal Ketamine and Esketamine (Spravato)
Intranasal ketamine and FDA-approved Spravato (esketamine): how dosing works, the REMS clinic visit, side effects, insurance coverage, and what to expect.
How Long Do Ketamine's Therapeutic Effects Last?
A detailed look at the duration of ketamine's antidepressant and analgesic effects, including factors that influence duration and strategies for maintaining benefit.
Ketamine for PTSD
An examination of ketamine's role in treating post-traumatic stress disorder, including clinical research findings, proposed mechanisms, and treatment approaches.
International Ketamine Research: Global Developments and Discoveries
A roundup of significant ketamine research from around the world, including clinical trials, regulatory developments, and scientific discoveries outside the United States.
Glutamate: The Excitatory Neurotransmitter Central to Ketamine's Action
Glutamate, the brain's excitatory neurotransmitter, and why its post-NMDA-blockade surge is central to how ketamine produces rapid antidepressant effects.
IV Ketamine Infusion
IV ketamine infusion therapy explained: standard 0.5 mg/kg protocol, session length, monitoring, side effects during infusion, and the typical 6-session series.
Continuous and Multi-Day Ketamine Infusions: Extended Protocols
Continuous and multi-day ketamine infusions for chronic pain: extended dosing protocols, indications, monitoring, and how they differ from single sessions.
History of Ketamine
History of ketamine from 1962 synthesis to surgical anesthetic, Vietnam-era field use, club drug years, the depression discovery, and FDA approval of Spravato.
Is Ketamine Legal for Therapy?
A clear explanation of ketamine's legal status in the United States and internationally, including FDA-approved uses, off-label prescribing, and controlled substance classification.
Ketamine for Chronic Pain
An overview of how ketamine is used to treat chronic pain conditions, including neuropathic pain, CRPS, fibromyalgia, and central sensitization syndromes.
Neuroplasticity
What neuroplasticity means, how the brain rewires itself, and why neuroplasticity is central to understanding ketamine's rapid antidepressant effects.
Ketamine for Treatment-Resistant Depression
How ketamine therapy is used to treat treatment-resistant depression (TRD), including clinical evidence, response rates, and what patients can expect.