neuroscience
Articles tagged with “neuroscience”
Shared Serotonin Signal Found in Two Fast Antidepressants
New research finds a shared serotonin mechanism across two rapid-acting depression treatments, reshaping how clinicians and patients understand how these drugs work.
Ketamine and Epigenetics: How Ketamine May Alter Gene Expression
An exploration of emerging research on ketamine's epigenetic mechanisms, including histone modification, DNA methylation changes, and how these processes may contribute to lasting antidepressant effects.
Ketamine and the Opioid System: How Ketamine Interacts with Opioid Receptors
An in-depth exploration of ketamine's interactions with the opioid receptor system, the scientific debate over whether opioid activity contributes to its antidepressant effects, and clinical implications.
Glutamatergic System: The Excitatory Signaling Network Behind Ketamine's Effects
An overview of the glutamatergic system — the brain's primary excitatory neurotransmitter network — and its central role in how ketamine produces rapid antidepressant effects.
GABA (Gamma-Aminobutyric Acid): The Brain's Primary Inhibitory Neurotransmitter
A definition of GABA — the brain's main inhibitory neurotransmitter — and its relationship to ketamine's mechanism of action and therapeutic effects.
How Ketamine Works: Science FAQ
Answers to frequently asked questions about ketamine's mechanism of action, how it differs from other treatments, and the science behind its antidepressant effects.
How Ketamine Works in the Brain: A Complete Neuroscience Guide
How ketamine works in the brain, step by step: NMDA blockade, glutamate surge, AMPA activation, BDNF release, and the synaptic rewiring behind rapid effects.
Ketamine and Neuroinflammation: Anti-Inflammatory Mechanisms
An exploration of ketamine's anti-inflammatory properties, the link between neuroinflammation and depression, and how these mechanisms contribute to therapeutic effects.
AMPA Receptor: Its Role in Ketamine's Antidepressant Effect
A glossary entry on the AMPA receptor, explaining what it is, how it functions, and why its activation is essential to ketamine's rapid antidepressant mechanism.
How Ketamine Works: A Detailed Scientific Explanation
How ketamine works in the brain step by step: NMDA blockade, glutamate surge, AMPA activation, BDNF release, mTOR signaling, and rapid new synapse formation.
Synaptogenesis: How Ketamine Promotes New Synaptic Connections
Synaptogenesis explained: how ketamine triggers new synaptic connections via BDNF and mTOR signaling, and why this drives lasting antidepressant effects.
BDNF (Brain-Derived Neurotrophic Factor): Definition and Role in Ketamine Therapy
Learn what BDNF (Brain-Derived Neurotrophic Factor) is, how it supports brain health, and why it is central to ketamine's rapid antidepressant mechanism.
Glutamate: The Excitatory Neurotransmitter Central to Ketamine's Action
Glutamate, the brain's excitatory neurotransmitter, and why its post-NMDA-blockade surge is central to how ketamine produces rapid antidepressant effects.
Neuroplasticity
What neuroplasticity means, how the brain rewires itself, and why neuroplasticity is central to understanding ketamine's rapid antidepressant effects.
NMDA Receptor
A comprehensive definition and explanation of the NMDA receptor — its role in the brain, its relevance to ketamine therapy, and why it matters for mental health treatment.
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