ketamine research
Articles tagged with “ketamine research”
Ketamine Brain Scans Reveal Depression Relief in Seniors
A new report finds ketamine tied to shifting brain activity in older adults with depression. Here's what it means and what remains unclear.
What Is the CADSS Dissociative Scale? Definition Explained
The CADSS dissociative scale measures dissociation intensity in ketamine research. Learn what it scores, who uses it, and how to read results.
Ketamine-Induced Cystitis: What Bladder Research Shows
Ketamine-induced cystitis is a documented bladder toxicity risk tied to heavy, frequent ketamine use. See what the research shows and when to seek care.
Ketamine Half-Life by Route of Administration Explained
Ketamine's half-life is about 2-3 hours for IV, IM, and oral doses, but 7-12 hours for esketamine (Spravato). Compare routes now.
MADRS Score Explained in Ketamine Clinical Trials
MADRS is the 10-item scale most ketamine and esketamine trials use to measure depression severity. Learn how scoring, response, and remission work.
Ketamine Metabolites: Norketamine and Hydroxynorketamine
Learn how ketamine breaks down into norketamine and hydroxynorketamine (HNK), why researchers study them, and what the evidence actually shows.
Ketamine Emergence Reaction: Definition & Symptoms
A ketamine emergence reaction is the confusion, vivid dreams, or agitation that can occur as the drug wears off. Learn causes, symptoms, and management.
Pain Specialist Links Ketamine to Less Drug Misuse
A pain specialist reports ketamine therapy may reduce substance misuse in chronic pain patients. Here's what the claim means and what to ask providers.
How to Read Ketamine Depression Research Studies Well
Learn how to read ketamine depression research studies, assess study quality, and compare findings. Start with this practical guide.
Ketamine, Psychedelics Tied to Brain Immune Signaling Shift
New research reported by Neuroscience News links ketamine and psychedelics to brain immune signaling in depression. Here's what's known and what isn't yet.
Subcutaneous Ketamine: Clinical Use, Onset, and Bioavailability
How subcutaneous ketamine works, its bioavailability vs IV, clinical settings where it's used, and questions to discuss with a licensed clinician.
Shared Serotonin Signal Found in Two Fast Antidepressants
New research finds a shared serotonin mechanism across two rapid-acting depression treatments, reshaping how clinicians and patients understand how these drugs work.
New Study: Ketamine Relieves Treatment-Resistant Depression
A new study reports ketamine relieves treatment-resistant depression and suicidal ideation. What the research means for patients exploring their options.
Ketamine Onset Time by Route: What the Research Shows
How quickly does ketamine work? Onset ranges from 30 seconds (IV) to 30 minutes (oral). Compare bioavailability, duration, and supervision needs by route.
Compounded Ketamine vs Spravato: Key Differences Explained
Compare compounded ketamine and Spravato (esketamine): FDA approval, bioavailability, supervision requirements, and clinical access differences.
Ketamine Dosing Explained: Therapeutic Ranges by Route
See ketamine dosing ranges for depression and pain across IV, intramuscular, intranasal, sublingual, and oral routes, plus how titration and safety checks work.
Ketamine and Epigenetics: How Ketamine May Alter Gene Expression
Ketamine and epigenetics: how histone acetylation, DNA methylation, and microRNA changes may help explain why ketamine's antidepressant effects last for days.
Rectal Ketamine Administration: Uses in Pediatric and Palliative Care
How rectal ketamine administration works, its bioavailability and onset, dosing in pediatric sedation, and its role in palliative and hospice pain care.
Ketamine for Chronic Fatigue Syndrome (CFS/ME)
Ketamine is not an approved ME/CFS treatment, but its anti-inflammatory and NMDA-blocking effects have researchers interested. See what the evidence shows.
Ketamine Treatment Methods Guide: Every Route of Administration Explained
Compare ketamine treatment methods by bioavailability, dosing, cost, and evidence, including IV infusion, Spravato, oral, sublingual, and IM injection.
How Ketamine Works in the Brain: A Complete Neuroscience Guide
How ketamine works in the brain, step by step: NMDA blockade, glutamate surge, AMPA activation, BDNF release, and the synaptic rewiring behind rapid effects.
Understanding Ketamine Safety: Risks, Side Effects, and Best Practices
A guide to ketamine safety: side effects, contraindications, drug interactions, long-term risks, and monitoring protocols explained for patients.
Set and Setting: How Environment Influences Ketamine Therapy Outcomes
How set (mindset) and setting (environment) shape ketamine therapy outcomes, with practical guidance for patients and clinicians on preparation and session design.
Ketamine and Neuroinflammation: Anti-Inflammatory Mechanisms
Ketamine reduces neuroinflammation at low clinical doses, but chronic high-dose use is linked to bladder inflammation. Here's what the research shows.
The Default Mode Network and How Ketamine Treats Depression
The default mode network drives rumination in depression. Learn how ketamine disrupts overactive DMN activity to produce rapid antidepressant effects.
Racemic Ketamine vs Esketamine: Pharmacological Comparison
Compare racemic ketamine and esketamine: NMDA receptor binding, dosing, FDA approval, insurance coverage, and typical treatment costs.
Ketamine-Assisted Treatment for Substance Use Disorders
How ketamine-assisted treatment for substance use disorders works, plus what clinical trials show for alcohol, opioid, and cocaine addiction.
Ketamine for Anxiety: How It Works, What the Research Shows, and What to Expect
Ketamine for anxiety may ease GAD, social anxiety, and panic symptoms within hours. See how it works, what studies show, and what to expect in treatment.
Ketamine Pharmacology: Absorption, Distribution, Metabolism
How ketamine is absorbed, distributed, metabolized, and eliminated, covering bioavailability by route, norketamine, HNK metabolites, and elimination half-life.
Ketamine for OCD: Emerging Research and Treatment Potential
Ketamine for OCD is an experimental, off-label treatment studied for people who don't respond to SRIs and ERP therapy. See what the clinical evidence shows.
Ketamine for Bipolar Depression: Research and Clinical Considerations
Ketamine trials show rapid relief for bipolar depression when paired with mood stabilizers, with low reported rates of manic switching. See the research.
How Ketamine Works: A Detailed Scientific Explanation
The ketamine mechanism of action explained: NMDA blockade, glutamate surge, AMPA activation, BDNF release, mTOR signaling, and new synapse growth.
Ketamine for Anxiety Disorders: Mechanisms and Clinical Evidence
Ketamine can reduce symptoms of generalized anxiety, social anxiety, and panic disorder within days. Learn how it works and what the evidence shows.
A Complete History of Ketamine: From Anesthetic to Antidepressant
Trace ketamine's history from its 1962 synthesis and Vietnam-era anesthesia to the 2000 depression discovery and 2019 FDA approval of Spravato.
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